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artP [2019-06-05 10:46:16]
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artP [2019-06-05 10:46:16]

high affinity arginine [SW|ABC transporter] (ATP-binding protein)
locus
BSU23980
pI
5.09
mw
28.16 kDa
protein length
255 aa Sequence Blast
gene length
768 bp Sequence Blast
function
arginine uptake
product
high affinity arginine [SW|ABC transporter] (ATP-binding protein)
essential
no
synonyms
yqiX
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,492,029 2,492,796

    The protein

    Protein family

  • bacterial solute-binding protein 3 family (according to Swiss-Prot)

    • Structure

  • [PDB|4YMX] (from Caldanaerobacter subterraneus, 43% identity) [pubmed|25848002]

    • [SW|Localization]

  • attached to the membrane via [protein|62BD291B91DB0358754957D84A1F3636C247A697|ArtQ] [Pubmed|10092453]
  • extracellular (signal peptide) [Pubmed|18957862], membrane [Pubmed|18763711]

    • Expression and Regulation

    Operons

    genes
    [gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]-[gene|62BD291B91DB0358754957D84A1F3636C247A697|artQ]-[gene|6882EF93EC82872B25C88104F62D6603D2514890|artR]
    description
    [Pubmed|12107147]

    regulatory mechanism

  • [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]

    • regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]
    • view in new tab

    Biological materials

    Mutant

  • GP1689 Δ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]-[gene|62BD291B91DB0358754957D84A1F3636C247A697|artQ]-[gene|6882EF93EC82872B25C88104F62D6603D2514890|artR])::''mls'', available in [SW|Jörg Stülke]'s lab
  • MGNA-C381 (yqiX::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2379 NBRP B. subtilis, Japan]
  • BKE23980 ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCCATTTCCCCCGTA, downstream forward: _UP4_TAAAAAAAAGCGGCTCAACT
  • BKK23980 ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCCATTTCCCCCGTA, downstream forward: _UP4_TAAAAAAAAGCGGCTCAACT

    • References

  • 10092453,18957862,12107147,18763711,11423008,23038252,25848002